S. IV 50:z4,z23:-¶

At a Glance


Antigenic Formula	`50:z4,z23:-`
Serogroup	O:50 (Z)
NCBI Pathogen Detection	View isolates

Background Information¶

Salmonella enterica subsp. houtenae serovar 50:z₄,z₂₃:- (antigenic formula: 50:z₄,z₂₃:-) is a serovar of the O:50 (Z) serogroup. This serovar is also known as serovar IV Flint. Serovar 50:z₄,z₂₃: was first isolated from three cultures in 1964 in the US: two were recovered from the stools of hospitalized male siblings, aged 10 and 27 months, both suffering from severe gastroenteritis at the time of isolation, and the third strain was isolated from a bird snake. This serovar was previously reported to cause systemic salmonellosis in a Florida manatee (Trichechus manatus latirostris). More specifically, necropsy and histopathological analysis revealed a chronic systemic bacterial infection affecting the renal, respiratory, lymphatic, and skeletal systems. In the US, serovar IV 50:z4, z23:- was found frequently in Florida but not nationally between 2017 – 2018.

Genetic Characteristics¶

Serovar IV 50:z₄,z₂₃:- has been found to be polyphyletic with four lineages identified and one stand-alone singleton that does not cluster with any other Salmonella IV 50:z₄,z₂₃:- isolates.

Animal Reservoir¶

Unknown, but based on the NCBI PD metadata, this serovar was isolated from cat, dog, cattle, manatee, kangaroo, bird, and lama.

Geographical Distribution¶

Based on the NCBI PD metadata, serovar IV 50:z₄,z₂₃:- has only been reported in the US, Canada, Brazil, the UK, Germany, and Taiwan.

Human/Animal Outbreaks¶

Year	Location	Associated source	Number of cases
2019	US: MN	Bubble tea¹	2

¹ Suspected. During the investigation, no source of contamination was identified. It is possible that they may share additional exposures at the market that were not reported.

S. IV 50:z4,z23:-¶

Background Information¶

Genetic Characteristics¶

Animal Reservoir¶

Geographical Distribution¶

Human/Animal Outbreaks¶

Border Rejections¶

Recalls¶

References¶